Why I’m Taking Science Policy Insider International

A View from Abroad

Mid-competition week for a panel reviewing proposals on genes and cells: the fifteen-minute clock starts, and the five of us assigned to this proposal dive in. We consider factors such as whether the proposer is early in their career and how the COVID pandemic might have affected their laboratory’s productivity. We carefully assess their plan for mentoring trainees, including their previous track record and plans. The excellence of the proposer is evaluated, not by raw bibliometric measures such as H-index, but by substantive contributions to the field. And we take a very close look at the proposal itself—not only in terms of intellectual merit, but also to make sure that it is distinct from the investigator’s other supported science. Is this an NIH study section? Nope. Is this an NSF panel? Again, no. This is a peer review for another G7 nation, to be unnamed in this post.

What struck me wasn’t that this country did peer review differently than NSF or NIH. What struck me was how similar it was. Same careful attention to mentoring. Same suspicion of bibliometrics. Same concern about overlaps with existing funding. I could have been in any panel room I’d sat in over three decades in Washington. And that’s when it hit me: among the wealthy nations that fund science, we’re all running variations on the same basic system. We argue about details – overhead rates, review criteria, funding durations – but we share fundamental assumptions about how science should work.

Thanks for reading sciencepolicyinsider! Subscribe for free to receive new posts and support my work.

Or so I thought. Until I stepped outside the world of science funding and began looking at how other countries organize technical knowledge. My second book project examines how Boeing, Airbus, and Embraer design commercial aircraft – and that research has revealed something I’d missed in all my years in government and academia.

Civic Epistemologies

The scholar Sheila Jasanoff has a concept called ‘civic epistemologies’ – the idea that different societies have fundamentally different ways of producing and validating knowledge. It’s not about organizational charts or funding mechanisms. It’s deeper than that. It’s about cultural assumptions: What questions are worth asking? What counts as evidence? Who gets to decide? How do we measure success?

When Americans design an airplane, we assume that technical decisions should be made by engineers based on data, with regulators checking compliance after the fact. Europeans embed social and labor concerns directly into the design process – workers’ councils have a say in production methods, and safety regulators are involved earlier. Brazilians organize around different assumptions entirely, shaped by their position as a developing economy entering a market dominated by established players.

Same engineering principles. Same physics. The same goal of building a safe, efficient aircraft. But fundamentally different answers to the question: Who should decide how this gets done?

I saw the same pattern as a working neuroscientist. American neuroscience tends to bet on fundamental discovery—map the circuits, understand the mechanisms, and applications would follow. Recording sea slug neurons during my training embodied this approach: study simpler systems, find conserved principles, apply them to humans. Europeans start closer to the clinic, organizing major research programs around disease categories and patient needs. Japanese neuroscience builds unusually tight links between academic labs and industry—electronics and engineering companies actively embedded in research networks, with clear paths toward commercialization: same neurons, same biology—different assumptions about how knowledge should flow from laboratory to society.

My new book project

So, where is this taking me? The short answer is I’m working on a new book about how American, European, and Brazilian cultures (think Boeing, Airbus, and Embraer) shape commercial aviation technology. Why planes? In my lifetime, I experienced firsthand the jet revolution: I started on the Comet, went on to the Pan Am 707s, and these days still enjoy the grandeur of the big twin aisle giants that connect us across oceans.

In the new book, I’m interested in comparing technical cultures through the lens of those jets (as technical artifacts). But beyond my lifetime fascination with aviation, the same questions apply to science policy itself: why do different countries organize technological knowledge differently? What can we learn from how other G7 nations fund science? And what cultural assumptions shape what gets built (airplanes OR research programs)?

Science Policy Insider Expands Its Scope

This brings me back to Science Policy Insider and where we’re headed. We are broadening our remit. In the future, we’ll expand to include a comparative analysis of research funding systems—both public agencies and private industry—drawing on insights from my aviation research. We’ll examine how different countries handle current challenges: AI governance, climate research, and research security.

On the practical side, we’ll provide insights for American researchers who work internationally or plan to—from navigating different grant systems to understanding why collaborations succeed or fail across cultural boundaries. And above all, we’ll consider what viewing American science policy from the outside reveals about our own system.

We’ll maintain our bi-weekly publishing schedule.

Science Policy Insider started with my promise to explain how American science policy really works from someone who was inside the system. Now we’re also going to explore what it looks like from the outside and what that perspective reveals about our own system.

I continue to invite readers’ questions, now not only about how things work in our own American discovery machine, but also about international science policy.

Bold Ventures in Science: NSF’s NEON and NIH’s BRAIN Initiative

My favorite projects…

As loyal readers know, these are my two favorite science initiatives. They stand out as beacons of progress: the National Science Foundation’s National Ecological Observatory Network (NEON) and the National Institutes of Health’s Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative. These groundbreaking endeavors showcase the commitment of U.S. science agencies to tackling complex, large-scale challenges that could revolutionize our understanding of the world around us and within us.

NSF’s NEON: A Continental-Scale View of Ecology

Imagine having a window into the ecological processes of an entire continent. That’s precisely what NEON aims to provide. Initiated in 2011, this audacious project is creating a network of ecological observatories spanning the United States, including Alaska, Hawaii, and Puerto Rico.

Yes, NEON has faced its share of challenges. The project’s timeline and budget have been adjusted since its inception, growing from an initial estimate of $434 million to around $469 million, with completion delayed from 2016 to 2019. But let’s be honest: when did you last try to build a comprehensive ecological monitoring system covering an entire continent? These adjustments reflected the project’s complexity and the learning curve in such a pioneering endeavor.

The payoff? NEON is now collecting standardized ecological data across 81 field sites from Hawaii to Puerto Rico and in between. This massive time series in some 200 dimensions will allow scientists to analyze and forecast ecological changes over decades. From tracking the impacts of climate change to understanding biodiversity shifts, NEON provides invaluable insights that could shape environmental policy and conservation efforts for future generations.

NIH’s BRAIN Initiative: Decoding Our Most Complex Organ

Meanwhile, the NIH’s BRAIN Initiative is taking on an equally monumental task: mapping the human brain. Launched in 2013, this project is aptly named, as it requires a lot of brains to understand… well, brains.

With annual funding that has grown from an initial $100 million to over $500 million, the BRAIN Initiative is a testament to the NIH’s commitment to unraveling the mysteries of neuroscience. Mapping all 86 billion neurons in the human brain by 2026 might seem a tad optimistic. But I’m increasingly impressed with our progress, and I am hopeful we’ll be able to get some meaningful statistics about variability across individuals.

The initiative has already led to the development of new technologies for studying brain activity, potential treatments for conditions like Parkinson’s disease, and insights into how our brains process information. It’s like a real-life adventure into the final frontier, except instead of outer space, we’re exploring the inner space of our skulls.

The Challenges: More Feature Than Bug

Both NEON and the BRAIN Initiative have faced obstacles, from budget adjustments to timeline extensions. But in the world of cutting-edge science, these challenges are often where the real learning happens. They’ve pushed scientists to innovate, collaborate, and think outside the box (or skull, in the case of BRAIN).

These projects have also created unique opportunities for researchers to develop new skills. Grant writing for these initiatives isn’t just an administrative hurdle; it’s a chance to think big and connect individual research to grand, overarching goals. It’s turning scientists into visionaries, and isn’t that worth a few late nights and extra cups of coffee?

Conclusion: Big Science, Bigger Possibilities

NEON and the BRAIN Initiative represent more than just large-scale scientific projects. They’re bold statements about the value of basic research and the importance of tackling complex, long-term challenges. They remind us that some questions are too big for any single lab or institution to answer alone.

As these projects evolve and produce data, they’re not just advancing our understanding of ecology and neuroscience. They’re also creating models for conducting science at a grand scale, paving the way for future ambitious endeavors.

So here’s to the scientists, administrators, and visionaries behind NEON and the BRAIN Initiative. They’re showing us that with enough creativity, persistence, and, yes, funding, we can tackle some of the biggest questions in science. And who knows? The next breakthrough in saving our planet or understanding consciousness could be hidden in the data they’re collecting right now.

What would SARS-CoV2 do inside the brain?

The paper Nadine Kabbani and I wrote in March/April got more traction today with this report in the FT (behind their firewall). Note that this latest original manuscript is actually still out to peer review at Altex, so please treat with caution.

But if Brain COVID19 were a thing, what might be going on? First, I think that the anosmia symptoms are pretty important here because olfactory odor receptors are actually part of the brain–the just hang out in your nose. If the virus gains access to the brain via those cells, then it potentially could use the wiring system of the nervous system as a superhighway. Second, the brain is actually separated from the rest of the adaptive immune system by the blood brain barrier. So virus in the brain can just chill–it’s not under constant attack from immune cells. The virus that causes Shingles actually does exactly this: after initially infecting a person (giving them Chickenpox), it awaits in neurons, for the right moment to reactivate. When it does, it produces the disease we know as Shingles.

What causes the reactivation? We don’t really know. And we have yet to see what a reactivated SARS-CoV2 might look like. I really hope we get a vaccine soon.

International science: at risk?

According to SCIENCE magazine, the NIH is taking a serious look at US funded research products (including ideas, data and intellectual property) leaking to other nations–particularly near-peer competitors such as China. This is not happening in a political vacuum: the current trade tensions between the US Administration and China come to mind. And there have been concerns from Congress even before the 2016 election.

I don’t doubt that there have been instances of bad behavior by individual scientists, particularly those with dual allegiances. But I also passionately believe that the really tough scientific questions require an intellectual approach–look at Higgs in particle physics or the various brain research initiatives. Big science requires a big tent.

I hope we don’t throw the baby out with the bath water here.