SfN05

Jim asked me to enter a blog with my thoughts on SfN05. As usual, SfN was a “stock market” of information, as a senior colleague called it, a feast of amazing lectures, posters, demonstrations, symposia, etc. To me, it is the personal meetings that most notably define SfN. Both the formally arranged one, e.g. with collaborators from out of town to discuss the status of the project or exchange data, and the informal ones, i.e. bumping into the right person at the right time, trading bits of information or planting the seed for more extensive exchanges down the road. Many of my own research projects (and I can very concretely think of recent grants and papers) have started just that way at previous SfN meetings. This year the sequence of formal and informal meetings was even more intense than in the past, nearly around the clock!

More generally, I think that the meeting had a lot of energy, movement, and scientific appeal. The presence of neuroinformatics in particular was pervasive – my impression is that databases and analysis tools are changing the face of neuroscience research the way bioinformatics did to molecular biology. The ratio of “secondary” discovery (from re-analysis of archived data, be those gene sequences, fMRI images, or neuronal reconstructions) over “primary” data collection is destined to only increase in the future. I was very pleased that our own results (George Mason, Krasnow Institute, and Computational Neuroanatomy Group) received a considerable level of attention and praise. This was also the first SfN meeting and poster presentation for many of our grad students, a milestone I am particularly proud of!

Giorgio

Confocal Imaging Facility for Krasnow

I think it is important for Krasnow to acquire the capabilities in cellular imaging that come along with a comprehensive confocal microscope system. This capability will be positive, not only for our existing investigators, but also for our future recruitments. Basically, we are looking for cellular imaging which will allow us not only focus in superbly on the interior structure and dynamics of cells (such as neurons) but also the capability to manipulate those intracellular spaces using such techniques as caged compounds.

In truth, this may involve the purchase of more than one instrument. I have been looking at both spinning disk and laser scanning models and both upright and inverted types. I imagine that our cellular imaging center will be structured in a similar manner to our new brain imaging center.

Accordingly, in the next several weeks I will be arranging for demonstrations from various potential vendors. I’m looking forward to the participation of our scientific staff in addition to other interested scientists at George Mason.

Jim

A retirement ceremony

This morning I went to Bolling Airforce Base for the retirement ceremony of one of my oldest friends. We were roommates for two of our four years of undergraduate education at Amherst College. He was retiring, a “full bird” colonel after 26 years of service that has taken him from heading up ROTC at Cornell to heading up the Russia, Eurasia and Africa office at the Defense intelligence Agency. Along the way he picked up a PhD in American-Eastern European affairs and headed up the intelligence operation for Nato’s southern flank during the Balkan crisis of the late 1990’s. His service is something that we are all better off for–it was a bittersweet moment, but also filled with a sense of his accomplishments. My hat is off to him.

Jim

Final thoughts: Society for Neuroscience Meeting 2005

A word picture: yesterday around 5 PM just outside the brand new Washington 7th St. Convention Center at the corner of 9th St. NW and Mt. Vernon Place. Thousands of neuroscientists were enjoying the indian summer balmy air. A woman DC traffic cop was at the center of the intersection directing rush hour with aplomb. And as I sat on the corner, waiting to head for dinner with an old friend from California, at least four colleagues walked up to say hello and catch up. All this as the sun was setting and the crowds surged against the cars, puctuated by the occaisional sirens. Welcome to Washington!

We had a wonderful George Mason Neuroscience social the night before–in a beauitful room with a view the overlooked the US Capitol. I was struck by what a growing and dynamic program we have….filled with optimism. That is something we can all savor.

Jim

Neuroscience Meeting blogging

It was a wonderful day at the annual Society for Neuroscience meeting
today. I found myself with former and current students and of course
more data than one could ever shake a stick at! One thing I did notice
was that modeling doesn’t really get broken out appropriately yet–we
had our poster in a session on place cells. Seems to me that we should
lobby for a couple of sessions of our own next time.

Jim

Neuroscience Meets Pedagogy: A Matter of Form

This week’s editorial in Science, “Pedagogy Meets Neuroscience,” is the crest of a wave that began back in June when The Journal of Neuroscience published the commentary, “Science Education: A Neuroscientist’s View of Translational Medicine” (Schwartz-Bloom R. 2005. JNAS, 25 (24): 5667-5669), and Nature printed, “Big Plans for Little Brains” (Volume 435, 1156-1158). The topics of each of these pieces address the potential for neuroscience to inform and reform educational policy, intervention, and practice. This issue lead to my interdisciplinary graduate training in educational psychology and neuroscience, which included experiments on the effects of Ritalin on learning and memory in hyperactive rats, and using EEG to explore the abilities of intellectually gifted and hyperactive adolescent boys to shift between academic and creative tasks. Michael Posner once shared with me videotaped discussions between cognitive scientists, neuroscientists, and education professionals brought together by a philanthropic organization in hopes of generating interdisciplinary research topics.

I have witnessed the approach-avoidance dance between the fields of neuroscience and education for about 9 years now. On one hand, neuroscience has been reticent until now to consider the paradigmatic influence that educational psychology could have on discerning relevant research hypotheses. Indeed, the neuroimaging methods we use to adequately explore cognition, its development, and the nature of individual differences are just beginning to mature from their infancy. In this same issue of Science, there is a report that anomolies in certain genes that guide brain development are now linked to dyslexia. But in many ways, the metric between neuroscience and education is still off. Cognition viewed in the lab doesn’t necessarily reflect “real-world” cognition, at least not in the way that practitioners think about it. On the other hand, educators have been quick to conform to whatever pieces of information about the brain they can learn from the popular press and self-proclaimed experts. Intervention techniques that currently exist perturb the plastic brain, but for how long?

John Bruer, President of the McDonnell Foundation, once proclaimed it a “bridge too far” to cross. Now, just recently, the National Science Foundation has laid the foundations of those bridges with their Science of Learning endowments to University of Washington, Stanford, Dartmouth, Carnegie-Mellon, and Boston University. In my own talks about the neuroimaging studies that my lab performs on nonverbal reasoning, I preface remarks to educational audiences with two main topics. First, why it looks like we know so much when we know so little. Indeed, until the advent of neuroimaging, members of the animal kingdom were our “age-old experts.” And second, the need for developing greater scientific literacy so that people are equipped with the skill to evaluate translated scientific information. The challenge on the front of science involves innovating experimentation that will allow us to characterize cognitive function with greater ecological validity so that neuroscience can potentially inform and reform how we educate. We also have a responsibility to promote scientific literacy. The challenge on the front of education is to refrain from conforming to ideas and information that are still new and unreplicated.

Introducing Layne Kalbfleisch

Professor Layne Kalbfleisch will be guest blogging an entry related to this week’s editorial in SCIENCE magazine by Elsbeth Stern “Pedagogy meets Neuroscience”. Layne is a professor here at Krasnow, co-chairs our imaging facility and runs KIDlab–Krasnow Investigations of Developmental Learning and Behavior. Welcome to Layne.

Donald Hebb

We had a wonderful seminar today from Richard Brown of Dalhousie
University on the life of Donald Hebb–who I believe was the
intellectual father of much of what goes on at the Krasnow Institute today.

For those of you who missed the seminar the abstract is here
(http://krasnow.gmu.edu/abstracts_frames/abs05/brown-11-7-05.htm) and
Richard will be presenting a poster at the history of neuroscience
session at the Society for Neuroscience meeting here in Washington which
begins at the end of this week.

I’d also like to welcome our colleagues in neuroscience from around the
world who may be visiting Krasnow and Washington this coming week. I
hope to see many of you at the Meeting.

Jim