Two wonderful Krasnow evenings…

The last two evenings have been just spectacular for the Institute. Monday evening, Krasnow’s Giorgio Ascoli, gave a lecture on “Virtual Brains” to an enthusiastic audience in Mason’s Center for the Arts in Fairfax. And yesterday afternoon’s Advisory Board meeting and subsequent Brain Imaging Center open house celebration was capped off by a very substantial gift pledge from Krasnow Advisory Board member Patricia Kluge. It’s weeks like this one that make my job so incredibly rewarding.

Kudos go to all of the Krasnow and Mason staff who worked so tirelessly to make these events successful.

Jim

Mirror neurons and autism

Ramachandran and Oberman on the possibility that the mirror system is involved in autism (click on the link above).

Money quote:
“An even more intriguing possibility would be to use biofeedback to treat autism or at least alleviate its symptoms. Doctors could monitor the mu waves of a child with autism and display them on a screen in front of the patient. If the child’s mirror neuron functions are dormant rather than completely lost, it may be possible for him or her to revive this ability by learning–through trial and error and visual feedback–how to suppress the mu waves on the screen. Our colleague Pineda is pursuing this approach, and his preliminary results look promising. Such therapies, though, should supplement rather than replace the traditional behavioral-training techniques.

Another novel therapeutic approach might rely on correcting chemical imbalances that disable the mirror neurons in individuals with autism. Our group (including students Mikhi Horvath and Mary Vertinsky) has suggested that specialized neuromodulators may enhance the activity of mirror neurons involved in emotional responses. According to this hypothesis, the partial depletion of such chemicals could explain the lack of emotional empathy seen in autism, and therefore researchers should look for compounds that stimulate the release of the neuromodulators or mimic their effects on mirror neurons. One candidate for investigation is MDMA, better known as ecstasy, which has been shown to foster emotional closeness and communication. It is possible that researchers may be able to modify the compound to develop a safe, effective treatment that could alleviate at least some of autism’s symptoms.”

A cautionary tale

Yesterday’s Sunday NY Times magazine has an excellent story of what can happen when a scientist goes bad. For young investigators it’s an important read.

Money quote:
“He presented fraudulent data in lectures and in published papers, and he used this data to obtain millions of dollars in federal grants from the National Institutes of Health — a crime subject to as many as five years in federal prison. Poehlman’s admission of guilt came after more than five years during which he denied the charges against him, lied under oath and tried to discredit his accusers.”

Weekend blogging

This has been a very busy weekend. We’re getting a manuscript ready
for submission, I’m finishing up a powerpoint for Tuesday’s Advisory
Board Meeting and I’m working on an editorial for the December issue
of The Biological Bulletin.

Interestingly the board presentation got me thinking about how much
is going on: three open searches, an on-going recruitment in addition
to the new space and the brain imaging center. The Institute could
find itself in the position next Fall of taking in as many as 22 new
scientific staff members in various groups. I sure hope we have the
space to accommodate everyone.

In the meantime, it’s about time to think about fundraising for
Krasnow Phase III. This will the the follow-on second 12,500 square
foot expansion that will take us up to around 50,000 total square
feet of research space.

Jim

Academic buzz

A wonderful New Yorker Review of William Clark’s new book “Academic Charisma and the Origins of the Research University” (click on the link above).

Money quote:

Today, by contrast, dwindling public support has forced university administrators to look for other sources of funding, and to assess professors and programs through the paradigm of the efficient market. Outside backers tend to direct their support toward disciplines that offer practical, salable results—the biological sciences, for instance, and the quantitative social sciences—and universities themselves have an incentive to channel money into work that will generate patents for them. The new regime may be a good way to get results, but it’s hard to imagine that this style of management would have found much room for a pair of eccentrics like James Watson and Francis Crick, or for the kind of long-range research that they did.

Evolution of post-synaptic proteins

SCIENCE’s Elizabeth Pennisi on Seth Grant’s work concerning the proteomic evolution of the post-synaptic milieu (click on the link above).

This is an intriguing idea: the notion that our increased cognitive power (as human animals) derives not from brain size, but rather from the biochemical complexity of our synapses.

Nicholas Humphrey’s new book on consciousness

John Searle has a comprehensive review in the New York Review of Books (click on the link above). He disagrees with Humphrey but lays out the author’s argument in sufficient detail to make one want to read the book.

I intend to.

Money quote from the review:

He agrees that the evolutionary account is not by itself sufficient to explain consciousness. But he thinks that with certain crucial additions we can account for qualitative subjectivity: “If this X factor [his expression for qualitative subjectivity] has to do with anything, it has to do with time.” He calls this aspect of consciousness the “extended present.” And he says we have no verbal way of describing the extended present. But he thinks we can understand it if we see how it resembles a work of art. He claims that we will get a deeper understanding of consciousness if we see the “analogy between a work of art and ‘a work of sensation.'” He thinks that studying Impressionism, Abstract Expressionism, and other kinds of art will enable us to explain what is so special about our conscious experience. For example, Humphrey writes, the painter Bridget Riley, a leading op artist,

explicitly acknowledges the “dual province of the senses,” making central to her vision the distinction between sensation and perception…. Riley is not interested in representing the outside world as she perceives it, as an impersonal fact. She wants only to show how it affects her—her eyes, her body.

Analogously, Humphrey continues, Monet, in his approach to painting a century earlier, “set out almost obsessively to capture the peculiar quality of present-tense experience,” or what he called “instantaneity.” For Humphrey, this is an example of how, in depicting a visual experience at a particular moment in time, some artists give precedence to describing how it feels to have that experience, rather than to describing the external realities that produced that experience. The conclusions that Humphrey draws from these observations, however, are difficult to follow:

Suppose, as an exercise in metaphor, we put a painting by Riley or Monet on the right-hand side of the mind-brain identity equation in place of the brain, will the painter’s tricks for depicting instantaneity genuinely help?

I think they not only help, they go right to the heart of it.

He thinks we have almost explained qualitative subjectivity, but we need one last thing, and that is feedback. To get consciousness we need a feedback mechanism whereby the “command signal” responds to the incoming stimulus by actually modifying the incoming sensory pathways in the brain. But he thinks the story that he told us already, about the primitive reaction of organisms to stimulus, is sufficient to explain the feedback mechanism. He writes, “Indeed, feedback has been a feature of sensation all along. Ever since the days when sensory responses were actual wriggles at the body surface, these responses have been having feedback effects by modifying the very stimulation to which they are a response.” So sustained feedback, together with a “very fine tuning,” by which he means “a precise matching of output with input, so as to provide exactly the right degree of reinforcement of the signal in the loop,” will produce consciousness. And the payoff, he tells us enthusiastically, the evolutionary advantage of all of this, is that it gives us a sense of “the Self.” It turns out that this is really the primary function of consciousness, not to give us information about the world, which comes from unconscious perception, but to give us a sense of the Self. And this also triumphantly answers the question why consciousness matters. “Consciousness matters,” he tells us, “because it is its function to matter. It has been designed to create in human beings a Self whose life is worth pursuing.”

Future of Computing: George Gilder at Wired

There’s a great article on the future of super-computing in Wired (click on the link above).

Money quote:

“Amid the beckoning fantasies of futurism, the purpose of whatever comes next – like that of today’s petapede – will be to serve the ultimate, and still the only general-purpose, petascale computer: the human brain. The brain demonstrates the superiority of the edge over the core: It’s not agglomerated in a few air-conditioned nodes, but dispersed far and wide and interconnected via myriad sensory and media channels. The test of the new global ganglia of computers and cables, worldwide webs of glass and light and air, is how readily they take advantage of unexpected contributions from free human minds, in all their creativity and diversity. Search and you shall find.”

Why I’m not at the Society for Neuroscience meeting

This year, for the first time in a while, I’ll not be at the Society for Neuroscience meeting (which starts tomorrow in Atlanta). This is a very large scientific meeting (typically roughly 25,000 folks register) and for my field of neuroscience, it’s really the only place where everybody in brain sciences gets together in one venue.

And it’s not just the scientific sessions–I’ve always also enjoyed tremendously the opportunity to get together with colleagues and friends who are at other institutions, but with whom ties are still very strong.

So why I am staying home at Krasnow?

Fundamentally, the reason is that with the addition of our expansion space, multiple on-going faculty searches, and the nearness of the operational starting-line for our brain imaging center, there’s just too many Krasnow-specific operational details that require close attention.

In the meantime I wish all of my colleagues an excellent meeting and I’m very much looking forward to next year in San Diego.

Neuro-counterterrorism

Going beyond deception detection, neuroscience may soon be able to play a more practical role in counterterrorism. The enabling technologies are non-invasive brain imaging (particularly with data-fusion from multiple imaging modalities), trans-cranial magnetic stimulation, virtual reality environments, and the terrabytes of newly shared neuroscience data indexed in massive databases.

The goals might be: 1) to gain insight into the brain states that are necessary and sufficient to subserve a terrorist act (particularly when the act results in the suicide of the perpetrator), 2) to use technologies to modify such brain states in a controlled fashion–in the laboratory first and subsequently the field and 3) to explore the use of artificial sensory inputs to transition brains from terrorist-permissive to the normative condition.

Ultimately, terrorism is a human act produced as a result of neuronal actions in a human brain. While human acts are often very complex in nature, many behaviors have been explained quite well at the neuronal level (e.g. addiction and drug abuse). If the neural basis can be understood, then interventions can be devised.