The NIH internal review of how it gives grants out is out: among the key ideas: funding paradigm breaking research, funding more first-time investigators and telling people honestly when they have no chance ever of succeeding (on the basis of their scientific creativity or lack thereof).
Additionally, there’s the notion of how funding small science is changing–imagine a future where big science (think National Labs and huge well-established research teams) create the data sets which are then mined by small-scale individual PI’s using computational tools.
Jim