Author: jlolds

Native Angeleno, professor of Neuroscience and Public Policy at George Mason University

120 Days Out…

It’s been four months now since I’ve left NSF and returned to my university. During that time, I’ve gotten my first grant, taught two courses and given sundry talks around the state all towards the notion that, in life science, for Virginia, the whole is more than the sum of the parts. In our Commonwealth, even with a wealth of research university talent, too often we compete with each other for the crumbs rather than going after the big prizes that are out there.

 

What do I mean by the crumbs? Well, at the university level, these are the sponsored research opportunities that would be meaningful and significant at the individual PI level, but that are not a good return on investment (of time and energy) on the part of the institution as a whole, to say nothing of the state.

 

Contrast that to what I saw routinely during my time at NSF—where institutions within a state would coalesce around competitions for major center awards (and larger)—each institution supporting her sisters in a complementary style. This type of energy was visible, not only for the usual suspects like California or Massachusetts, but also for states that one might not expect.

 

I’ll be writing more about this subject matter in future blog entries….

Fusion: just around the corner? Redux

This interesting news about a collaboration between MIT and Commonwealth Fusion Inc (at Nature and potentially behind a firewall for some readers). In any case, the key idea here is that a new generation of superconductors will be used to create a magnetic confinement for the hot fusion plasma.

Many years ago, before I went to graduate school, during an internship on the Hill, I got very interested in fusion. But that was several energy crises ago. These days I would be interested in fusion power as a potential play for mitigating climate change….or possibly Bitcoin mining (not).

Adult neurogenesis? Not so much in humans

This is a huge result, making NPR and published in Nature, here. Since the discovery of adult neurogenesis in rodent models, it has been assumed by many (but not all) that we humans did the same thing. The assumption was that we grow new neurons every day throughout our lives.

Aside: actually that assumption was contrary to what many of us were taught. Before the discovery of rodent adult neurogenesis, it was thought humans stopped producing new nerve cells with the onset of adulthood.

The latest findings indicate that in humans, the production of new neurons slows down by age 7 and is gone by age 13. That’s shocking. What was the selection pressure for loosing such a phenotype from rats and mice?

Teaching again…

I am now three weeks into the semester and surprisingly, it’s been fairly easy.  The routine of teaching, grading, seminar preparation and the like are relaxing, even enjoyable. My students are graduate level in the School of Public Policy at George Mason. Because we are in D.C., some of my students are as senior as I am. And, I am learning from all of them.

At the same time, I have started a book project and am busy shopping out an Op Ed about the  President’s science budget–which hasn’t been released yet. Although… there was a leak that made it to the Washington Post in the last day or so.

For fun, over Spring Break, I’ll be headed to Paris with my wife. We plan to take advantage of all the excellent advice that we have received from friends and even ex-colleagues at NSF. So enjoying life…

Graduate Tuition Support at NSF

One thing that I didn’t know, before I came to NSF in 2014 was that support for graduate student research assistants as part of regular research grants includes tuition support that is not capped. According to this NSF FAQ:

Tuition remission is generally treated as part of an organization’s fringe benefit rate or as a direct cost. NSF’s policy is that colleges and universities should budget tuition remission consistent with its established indirect cost rate methodology and negotiated rate agreement. If tuition remission is budgeted as a direct cost, it should be listed in the “Other” category of the Budget under “Other Direct Costs.

Note that there is nothing about a cap in the above guidance.

In contrast, NIH does cap tuition support for graduate research assistants at around $16K. Here is the relevant NIH policy:

Undergraduate and Predoctoral Trainees and Fellows:  For institutional training grants (T32, T34, T35, T90, TL1, TL4) and individual fellowships (F30, F31), an amount per predoctoral trainee equal to 60% of the level requested by the applicant institution, up to $16,000 per year, will be provided.

This difference between the two science agencies is trivial for a lot of cases, were graduate students are paying in-state tuition at a public university. You can find some of the relevant data from the College Board here. However, in the case of some of the private research universities, this can be a very large amount of money. Here is the relevant tuition information for Princeton. And here in the same for Boston University. Even for public institutions, the out-of-state tuition can be very large in comparison to $16K (Rackham graduate school, University of Michigan).

Taken to its logical conclusion, NSF risks becoming a tuition-support agency instead of a science agency as tuition costs continue to rise across the country. This makes no sense. NSF should cap tuition support just like NIH does.

The communications problem…

As in the communications problems of scientists as they try to explain the intellectual merit of their work to non-scientists in plain language. Here’s a terrific essay by Samuel Matlack on that problem within the context of physics. This is not some feel-good exercise. Unless and until scientists develop this knack, they will continue to be viewed with skepticism by the folks who hold the purse strings.

Chinese Super-Science

Robert Samuelson has an op ed piece in today’s WAPO on how China has become a science superpower. The piece was timed with the release of NSF’s Science Indicators annual report (currently unavailable due to the government shutdown). I was last in China six years ago and it was clear even then that the Chinese were aiming, not just to become a peer of the US, but to exceed it in all areas of science and technology. Since that visit, we have seen the Chinese leap forward in Astronomy (the largest radio telescope), quantum computing (the world’s only satellite-based quantum encryption system), biomedical research (clinical studies that have statistical power far beyond those in the west) and even ecology (with their distributed environmental sensor network).

At the same time, US investments in science and technology have been quite stagnant. For Fiscal Year 2018, President Trump proposed an 11% cut to the NSF. He proposed an even larger cut of 22% for the NIH. These proposed cuts follow years of essentially flat funding during the Obama administration.  From a GDP perspective it’s even worse! Countries like South Korea, Germany and Japan made larger investments in science relative to their economy size.

If this trend continues, China will become the essential nation from a science perspective. And the geo-political consequences of that could be dire. Leading in science historically has led to non-incremental advances that create strategic surprise (e.g. nuclear weapons, the Internet, lasers). Imagine a US President being told that our spy satellites have been hacked leaving us blind to missile launches. Or that the location of our nuclear submarines was now available in real time to our global competitors?

What can be done? For one thing, it’s useful to remember that in the process of creating a budget, the President proposes, but Congress disposes. It is essential to reach out to members of Congress and let them know how important science is to the security of this country. But even more importantly, it’s time to open the channels of communication between those who are skeptical of the value of science investment and science advocates (including practitioners). In a recent conversation with one of this country’s most prominent science advocates, it became clear to me that science has taken on a political label that is not helpful. Science should not be political. Otherwise, it will become just another special interest in the eyes of its stakeholders. And the future of science is too important for that fate.

Origin of Life and NSF

There are many interesting open scientific questions, but one of the most intriguing is how did life originate in the universe. This is the central question of astrobiology and this week three astronomers authored a commentary in Nature that argues, among other things, for NSF to “replace elements…of the Astronomy, Geophysics and Ecosystem Studies program…by one exoplanetary systems science program.” The lead author, Caleb Scharf is the director of astrobiology at Columbia University.

Origin of life biology goes far beyond the study of exoplanets, as the authors acknowledge. Fundamental questions in redox chemistry far from chemical equilibrium lead to the origins of metabolism, massively conserved across earth’s living forms. At the same time, the information flow from DNA to RNA and thence to proteins drives questions about the origin of the ribosome translation machinery. In 2015, while I was still heading up NSF BIO, we collaborated with NASA to fund an IDEAS lab to explore across these two threads (metabolism and RNA). These are two communities of thought that don’t often communicate.

But Scharf and his co-authors raise important points. There needs to be better cross-talk between astronomy, geosciences and life sciences if we are to make progress. I am not averse to supporting a reorganization of NSF programs in support of such trans disciplinary cross-pollination, but will just point out that it’s often easier to ignore bureaucratic boundaries than to redraw them.